Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.
نویسندگان
چکیده
The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer disease (AD) centers that are conducting a multifaceted prospective biomarker study in individuals at-risk for autosomal dominant AD (ADAD). DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic ADAD mutation carriers and their non-carrier family members to determine the pathochronology of clinical, cognitive, neuroimaging, and fluid biomarkers of AD. This article describes the structure, implementation, and underlying principles of DIAN, as well as the demographic features of the initial DIAN cohort.
منابع مشابه
Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimerâ•Žs disease: Results of the DIAN study
Dominantly Inherited Alzheimer Network; and et al, ,"Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimer's disease: Results of the DIAN study. Objective. We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alz...
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OBJECTIVE To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network. METHODS Eighty-three mutation carriers and 37 asymptomatic noncarriers from...
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عنوان ژورنال:
- Clinical investigation
دوره 2 10 شماره
صفحات -
تاریخ انتشار 2012